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Oxidation of di- and polyamines: In vitro effect of amino aldehydes on the vitality of Leishmania promastigotes

TitleOxidation of di- and polyamines: In vitro effect of amino aldehydes on the vitality of Leishmania promastigotes
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2010
AuthorsMassa, Silvia, Spanò D., Pintus F., Medda R., and Floris G.
JournalMedicinal Chemistry Research
Volume19
Pagination77-83
ISSN10542523
Keywords1 (3 aminopropyl) 4 aminobutanal, 4 aminobutyraldehyde, 5 aminopentanal, amine oxidase (copper containing), aminoaldehyde, antiparasitic agent, article, cadaverine, cell density, cell proliferation, chemical structure, dialdehyde, growth inhibition, in vitro study, Leishmania infantum, nonhuman, oxidation, promastigote, Putrescine, spermidine, spermine, unclassified drug
Abstract

The aminoaldehydes 4-aminobutanal and 5-aminopentanal, derived from the oxidation of the diamines putrescine and cadaverine, and 1-(3-aminopropyl)-4- aminobutanal and aminodialdehyde, derived from the oxidation of the polyamines spermidine and spermine, were produced utilizing a copper amine oxidase (CAO) from Euphorbia characias latex and tested with in vitro cultivation of Leishmania infantum promastigotes. Whereas the aminoaldehydes derived from the oxidation of the diamines were stimulating factors for growth of Leishmania infantum promastigotes, the aldehydes derived from polyamines oxidation had a drastic inhibitory effect on the vitality and growth of these parasites. Thus, a double scenario arises, showing the use of aldehydes from diamines to obtain a large number of organisms of Leishmania infantum promastigotes to use in serological studies, whereas the aldehydes derived from polyamines could be used as a new strategy for therapeutic treatment against these parasites. © 2009 Birkhäuser Boston.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-76449099465&doi=10.1007%2fs00044-009-9173-0&partnerID=40&md5=d8c4e809097c073386bf5f739d9a6af9
DOI10.1007/s00044-009-9173-0
Citation KeyMassa201077