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Effects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production

TitleEffects of GSM-modulated radiofrequency electromagnetic fields on B-cell peripheral differentiation and antibody production
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2006
AuthorsNasta, F., Prisco M.G., Pinto Rosanna, Lovisolo G.A., Marino Carmela, and Pioli Claudio
JournalRadiation Research
Volume165
Pagination664-670
ISSN00337587
Keywordsanimal cell, animal experiment, Animals, antibody blood level, Antibody Formation, antibody production, antigen specificity, article, B lymphocyte differentiation, B-Lymphocytes, cell differentiation, Cells, Cellular Phone, controlled study, Cultured, Dose-Response Relationship, electromagnetic field, Electromagnetic Fields, Female, Global positioning system, Global System for Mobile Communication, immune response, immunoglobulin G antibody, immunoglobulin M antibody, Inbred C57BL, lipopolysaccharide, Mice, Microwaves, mobile phone, mouse, nonhuman, priority journal, Radiation, radiation absorption, Radiation Dosage, radiation dose, Radiation exposure, radiofrequency radiation, Spleen, Whole-Body Irradiation
Abstract

We examined the effects of in vivo exposure to a GSM-modulated 900 MHz RF field on B-cell peripheral differentiation and antibody production in mice. Our results show that exposure to a whole-body average specific absorption rate (SAR) of 2 W/kg, 2 h/day for 4 consecutive weeks does not affect the frequencies of differentiating transitional 1 (T1) and T2 B cells or those of mature follicular B and marginal zone B cells in the spleen. IgM and IgG serum levels are also not significantly different among exposed, sham-exposed and control mice. B cells from these mice, challenged in vitro with LPS, produce comparable amounts of IgM and IgG. Moreover, exposure of immunized mice to RF fields does not change the antigen-specific antibody serum level. Interestingly, not only the production of antigen-specific IgM but also that of IgG (which requires T-B-cell interaction) is not affected by RF-field exposure. This indicates that the exposure does not alter an ongoing in vivo antigen-specific immune response. In conclusion, our results do not indicate any effects of GSM-modulated RF radiation on the B-cell peripheral compartment and antibody production and thus provide no support for health-threatening effects. © 2006 by by Radiation Research Society.

Notes

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-33744820836&doi=10.1667%2fRR3555.1&partnerID=40&md5=6acf357af975e11ce51c2a1acc5828f9
DOI10.1667/RR3555.1
Citation KeyNasta2006664