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Clonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines.

TitleClonal anergy to staphylococcal enterotoxin B in vivo: selective effects on T cell subsets and lymphokines.
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication1993
AuthorsBaschieri, Selene, Lees R K., Lussow A R., and MacDonald H R.
JournalEuropean journal of immunology
Volume23
Pagination2661-6
Date Published1993 Oct
ISSN0014-2980
Keywordsalpha-beta, Animals, antigen, Antigens, CD4-Positive T-Lymphocytes, CD8, Enterotoxins, Gene expression, Immune Tolerance, Inbred BALB C, Lymphokines, Mice, Receptors, Staphylococcus aureus, Superantigens, T-Cell, T-Lymphocyte Subsets
Abstract

Injection of bacterial superantigens such as staphylococcal enterotoxin B (SEB) in adult mice results in initial proliferation of SEB-responsive V beta 8+ T cells followed by induction of a state of non-responsiveness frequently referred to as clonal anergy. We show here that SEB-induced anergy involves selective changes in lymphokine production and that it affects CD4+ V beta 8+ and CD8+ V beta 8+ T cells in different fashions. Whereas both CD4+ V beta 8+ and CD8+ V beta 8+ cells from anergic mice exhibit strongly reduced proliferative capacity and interleukin(IL)-2 production upon restimulation with SEB either in vivo or in vitro the CD8+ subset from SEB-injected mice produces other lymphokines (such as interferon(IFN)-gamma) at normal or slightly increased levels in response to SEB. Changes in the levels of production of IL-2 and IFN-gamma protein correlated well with mRNA accumulation both in vivo and in vitro. Collectively these data suggest that superantigen-induced anergy involves selective changes in signal transduction and/or gene regulation in T lymphocytes.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0027524870&doi=10.1002%2feji.1830231041&partnerID=40&md5=8a430045ef99884b39b0c79ed0a2f426
DOI10.1002/eji.1830231041
Citation Key5419