Sorry, you need to enable JavaScript to visit this website.

Heat-shock proteins as dendritic cell-targeting vaccines–getting warmer.

TitleHeat-shock proteins as dendritic cell-targeting vaccines–getting warmer.
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2013
AuthorsMcNulty, Shaun, Colaco Camilo A., Blandford Lucy E., Bailey Christopher R., Baschieri Selene, and Todryk Stephen
JournalImmunology
Volume139
Pagination407-15
Date Published2013 Aug
ISSN1365-2567
KeywordsAdaptive Immunity, Animals, Bacterial Vaccines, Cancer Vaccines, Cell Surface, Dendritic Cells, Heat-Shock Proteins, Humans, Immunity, Innate, lymphocyte activation, Receptors, Synthetic, T-Lymphocytes, Vaccines, Viral Vaccines
Abstract

Heat-shock proteins (hsp) provide a natural link between innate and adaptive immune responses by combining the ideal properties of antigen carriage (chaperoning), targeting and activation of antigen-presenting cells (APC), including dendritic cells (DC). Targeting is achieved through binding of hsp to distinct cell surface receptors and is followed by antigen internalization, processing and presentation. An improved understanding of the interaction of hsp with DC has driven the development of numerous hsp-containing vaccines, designed to deliver antigens directly to DC. Studies in mice have shown that for cancers, such vaccines generate impressive immune responses and protection from tumour challenge. However, translation to human use, as for many experimental immunotherapies, has been slow partly because of the need to perform trials in patients with advanced cancers, where demonstration of efficacy is challenging. Recently, the properties of hsp have been used for development of prophylactic vaccines against infectious diseases including tuberculosis and meningitis. These hsp-based vaccines, in the form of pathogen-derived hsp-antigen complexes, or recombinant hsp combined with selected antigens in vitro, offer an innovative approach against challenging diseases where broad antigen coverage is critical.

Notes

cited By 27

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84878717813&doi=10.1111%2fimm.12104&partnerID=40&md5=6cb37c632036783986450024857d00f2
DOI10.1111/imm.12104
Citation Key5423