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The ethanolic extract of Corylus avellana L. drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells

TitleThe ethanolic extract of Corylus avellana L. drives a microRNA-based cytotoxic effect on HepG2 hepatocarcinoma cells
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2023
AuthorsPierdomenico, Maria, Bacchetta Loretta, and Benassi Barbara
JournalNatural Product Research
Type of ArticleArticle
ISSN14786419
Abstract

An ethanolic extract of Corylus avellana L. hazelnut was characterised by liquid chromatography coupled to high resolution mass spectrometry. We here evaluated the in vitro cytotoxic response to such extract in HepG2 cells and tried to depict the underlying mechanism(s) in terms of microRNA-34b/c involvement. Following long-term exposure (144h) of HepG2 cells with 0.04-0.4 mg/ml of hazelnut extract, we demonstrated that miR-34 precursor RNA and both mature miR-34b and miR-34c molecules underwent a significant stimulation (>2-fold change, p < 0.05) in cells treated with the highest concentration. The epigenetic modulation was accompanied by the inhibition of cell proliferation, the decrease of viability and activation of apoptosis at 144h of treatment with 0.4 mg/ml of hazelnut. These in vitro findings demonstrate the cytotoxic effect of the C. avellana extract in HepG2 cells and open the way to in vivo validation of possible application of hazelnut-based extracts, and/or its metabolites, as promising epigenetics drugs. © 2023 Informa UK Limited, trading as Taylor & Francis Group.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85178219671&doi=10.1080%2f14786419.2023.2287170&partnerID=40&md5=977ada84705c16711e3e9a5379856d2a
DOI10.1080/14786419.2023.2287170
Citation KeyPierdomenico202301
PubMed ID38013231