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Comparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities

TitleComparative Chemical Analysis of Eight Punica granatum L. Peel Cultivars and Their Antioxidant and Anti-Inflammatory Activities
Publication TypeArticolo su Rivista peer-reviewed
Year of Publication2022
AuthorsParisi, V., Santoro V., Donadio G., Bellone M.L., Diretto Gianfranco, Sandri C., Mensitieri F., De Tommasi N., Piaz F.D., and Braca A.
JournalAntioxidants
Volume11
ISSN20763921
Abstract

A comparative quali-quantitative study of the peel extracts of eight Punica granatum cultivars obtained from underexploited areas of South Italy was carried out in order to valorize them as health-promoting by-products. The results showed that all of the samples possessed 45 ellagitannins, consisting mainly of polyhydroxyphenoyls; 10 flavonoids, belonging to flavonol, flavone, and catechin classes; and 2 anthocyanins. The most representative compounds underwent quantification through a LC-MS/MS multiple reaction monitoring (MRM)-based method; their qualitative profile was almost superimposable, while variability in the quantitative phenolic content was observed. The antioxidant activity was investigated using cell-free and cell-based assays. The in vitro anti-inflammatory potential was also studied by monitoring three typical markers of inflammation (IL-1β, IL-6, and TNF-α). Moderate differences in both activities were observed between the cultivars. Results showed that all of the investigated peels have a potential use as healthy bioactive phytocomplexes due to the interesting antioxidant and anti-inflammatory activities; in particular from the bioinformatic approaches a series of compounds, including galloyl-, pedunculagin-and ellagic acid-based, were found to be highly correlated with bioactivity of the extracts. Finally, the bioactivities showed by a Campanian local cultivar, ‘Granato di Aiello del Sabato’, could promote its cultivation by local farmers and germplasm conservation. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

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URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85148071819&doi=10.3390%2fantiox11112262&partnerID=40&md5=5fd4b4cedda288b52246169cfc9b2a7d
DOI10.3390/antiox11112262
Citation KeyParisi2022