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An E7-based therapeutic vaccine protects mice against HPV16 associated cancer

TitoloAn E7-based therapeutic vaccine protects mice against HPV16 associated cancer
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2009
AutoriVenuti, A., Massa Silvia, Mett V., Vedova L.D., Paolini F., Franconi Rosella, and Yusibov V.
RivistaVaccine
Volume27
Paginazione3395-3397
ISSN0264410X
Parole chiaveanimal cell, animal experiment, animal model, Animals, antineoplastic activity, article, cancer immunization, cancer inhibition, cancer survival, cancer vaccine, Clostridium thermocellum, controlled study, dosage schedule comparison, drug purification, drug synthesis, Experimental, Female, glucan glucosidase, Human papillomavirus type 16, Inbred C57BL, LicKM E7GGG vaccine, Mice, mouse, Neoplasm Transplantation, Neoplasms, Nicotiana benthamiana, nonhuman, Oncogene Proteins, Papillomavirus Infections, Papillomavirus Vaccines, priority journal, protein E7, provocation test, Synthetic, Tobacco, tumor growth, unclassified drug, uterine cervix cancer, vaccination, Vaccines, Viral
Abstract

Plant-derived vaccines represent an attractive strategy for cancer immunotherapy due to their relative safety and cost-effectiveness. We evaluated the anti-tumour activity of a Nicotiana benthamiana produced vaccine candidate based on the non-transforming E7 protein of HPV-16 fused to β-1,3-1,4-glucanase of Clostridium thermocellum. Two doses of vaccine at two week intervals were administered to groups of C57BL/6 mice starting 3 or 6 days after challenge with tumourigenic E7-expressing TC-1* cells. Inhibition of tumour growth and increased survival was observed in both groups treated with vaccine. These data suggest the potential of plants as a platform for producing therapeutic vaccines. © 2009 Elsevier Ltd. All rights reserved.

Note

cited By 29

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-67349204308&doi=10.1016%2fj.vaccine.2009.01.068&partnerID=40&md5=be8a57c9df4704859b9ee6b108df6a54
DOI10.1016/j.vaccine.2009.01.068
Citation KeyVenuti20093395