Sorry, you need to enable JavaScript to visit this website.

The estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways

TitoloThe estrogen receptor beta agonist diarylpropionitrile (DPN) inhibits medulloblastoma development via anti-proliferative and pro-apototic pathways
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2011
AutoriMancuso, Mariateresa, Leonardi Simona, Giardullo Paola, Pasquali Emanuela, Borra F., Stefano I.D., Prisco M.G., Tanori Mirella, Scambia G., Majo V.D., Pazzaglia Simonetta, Saran Anna, and Gallo D.
RivistaCancer Letters
Volume308
Paginazione197-202
ISSN03043835
Parole chiave1, 3, 5 tris(4 hydroxyphenyl) 4 propylpyrazole, animal, animal experiment, animal model, animal tissue, Animals, Apoptosis, article, cancer inhibition, cancer prevention, cell proliferation, controlled study, diarylpropionitrile, Disease Models, drug mechanism, estrogen receptor beta, Female, immunohistochemistry, male, medulloblastoma, Mice, mouse, Mus, Nitriles, nonhuman, ovariectomy, priority journal, Propionates, signal transduction
Abstract

Gender-related differences in medulloblastoma (MB) development have been reported with a higher incidence in males (slightly above 60%) than in females, female gender being also a significantly favorable prognostic factor in MB. The present study focused on the evaluation of the mechanisms by which estrogens protect against MB formation. To this end, we used a well characterized mouse model of MB - the Patched1 heterozygous mice. Ovariectomized mice were treated with 2,3-bis(4-hydroxyphenyl)-propionitrile (DPN), a highly potent ERβ agonist, or 4,4',4″-(4-propyl-[1. H]-pyrazole-1,3,5-triyl) trisphenol (PPT), a highly potent ERα agonist. Our results show that the ERβ selective agonist DPN significantly inhibits development of MB preneoplastic lesions when compared with untreated ovariectomized mice, restoring the final incidence to that observed in the intact controls, and that these effects were achieved via activation of anti-proliferative and pro-apototic pathways. On the other hand, the ERα selective agonist PPT did not influence MB tumorigenesis relative to untreated ovariectomized mice. © 2011 Elsevier Ireland Ltd.

Note

cited By 16

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-79959558098&doi=10.1016%2fj.canlet.2011.05.004&partnerID=40&md5=205eb09122408a5b02f282fe5a0c98fb
DOI10.1016/j.canlet.2011.05.004
Citation KeyMancuso2011197