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Clonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo.

TitoloClonal expansion precedes anergy and death of V beta 8+ peripheral T cells responding to staphylococcal enterotoxin B in vivo.
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1991
AutoriMacDonald, H R., Baschieri Selene, and Lees R K.
RivistaEuropean journal of immunology
Volume21
Paginazione1963-6
Data di pubblicazione1991 Aug
ISSN0014-2980
Parole chiaveAnimals, antigen, Antigens, CD4, CD8, Cell Survival, Differentiation, Enterotoxins, Female, Inbred BALB C, Interleukin-2, Mice, Receptors, Staphylococcus aureus, T-Cell, T-Lymphocyte, T-Lymphocytes
Abstract

Staphylococcal enterotoxin B (SEB) selectively stimulates T cells bearing T cell receptor V beta 8 domains and hence provides a useful model to study immunity and tolerance in vivo. We show here that V beta 8+ T cells in both CD4+ and CD8+ subsets expand dramatically (fivefold) in lymphoid tissues of mice 2-4 days following injection with SEB. This initial clonal expansion, which is accompanied by a transient hyper-reactivity to SEB, is followed by a rapid decrease in V beta 8+ cells and a concomitant induction of specific non-responsiveness which persists for at least 30 days. Selective death of V beta 8+ cells occurs during this latter phase. Taken together, our data indicate that clonal expansion, anergy and death can occur as sequential stages of an immune response in vivo.

Note

cited By 276

URLhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-0025767045&doi=10.1002%2feji.1830210827&partnerID=40&md5=ee264bc6ab24791e7e5fcb30b521144c
DOI10.1002/eji.1830210827
Citation Key5424