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In vivo responses of CD4+ and CD8+ cells to bacterial superantigens.

TitoloIn vivo responses of CD4+ and CD8+ cells to bacterial superantigens.
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione1992
AutoriHerrmann, T, Baschieri Selene, Lees R K., and MacDonald H R.
RivistaEuropean journal of immunology
Data di pubblicazione1992 Jul
Parole chiaveAnimals, Antigens, Bacterial, CD4, CD8, Cytotoxicity, Enterotoxins, Immunologic, Inbred BALB C, lymphocyte activation, Lymphokines, Mice, T-Lymphocytes

Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds to major histocompatibility complex (MHC) class II molecules and specifically activates T cells bearing V beta 8 T cell receptor domains. We have compared several aspects of the response of CD4+ and CD8+ T cell subsets to SEB in vivo. V beta 8+ cells in both subsets proliferated to a similar extent upon SEB injection. Furthermore, mRNA for interferon-gamma was induced in both subsets with similar kinetics and SEB dose-response. Finally CD8+ (but not CD4+) T cells from SEB-injected mice exhibited SEB-specific lysis of MHC class II-bearing target cells. Collectively, these data indicate that the CD4: MHC class II interaction confers no detectable selective advantage to CD4+ cells in the in vivo response to SEB. The observed effector functions of both subsets may contribute to SEB-induced immunopathology.


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Citation Key5421