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Efficacy of Hydroponically Cultivated Saffron in the Preservation of Retinal Pigment Epithelium

TitoloEfficacy of Hydroponically Cultivated Saffron in the Preservation of Retinal Pigment Epithelium
Tipo di pubblicazioneArticolo su Rivista peer-reviewed
Anno di Pubblicazione2023
AutoriDi Paolo, Mattia, Corsi Francesca, Maggi Maria, Nardi Luca, Bisti Silvia, Piano Ilaria, and Gargini Claudia
RivistaMolecules (Basel, Switzerland)
Type of ArticleArticle
Parole chiaveCell Line, coloring agent, Coloring Agents, Crocus, Hydrogen Peroxide, metabolism, Oxidative stress, reactive oxygen metabolite, Reactive Oxygen Species, Retinal Pigment Epithelium

Saffron treatment is a broad-spectrum therapy used for several retinal diseases, and its effectiveness depends on a particular molecular composition (REPRON® saffron). Its production requires specific crops and procedures that, together with low yields, make this spice expensive. To reduce costs, the use of hydroponic crops is gradually increasing. In this study, we tested the protective properties of a hydroponic saffron (sH) batch in models of retinal pigmented epithelium (RPE) degeneration. ARPE-19 cells were pretreated with 40 µg/mL saffron and exposed to different types of damage: excess light and retinol (LE + RET) or oxidative stress (H2O2). After analyzing the composition of all saffron types with spectroscopy, we performed cell viability and immunofluorescence analysis for both protocols. We compared the sH results with those of a validated batch of saffron REPRON® (sR) and those of a saffron non-REPRON® (sNR) batch. sH and sR, which we found had the same chemical composition, were more effective than sNR in increasing cell survival and attenuating the morphological changes related to apoptosis. In conclusion, hydroponic culturing is a suitable strategy to produce high-quality saffron to reduce costs and increase the accessibility of this promising treatment for retinal degeneration.


Cited by: 0; All Open Access, Gold Open Access

Citation KeyDi Paolo2023
PubMed ID36838685